![]() ![]() ![]() We work with self published Indie authors and New York Times best selling authors. For more information on our custom book printing services, contact the team at Linemark today.People do judge a book by its cover, so make sure yours is a great one! Having a great book cover design is extremely important for any author who wants their book to be successful. We’ll work with you to determine the best format for your self-publishing dreams and help make them a reality. At Linemark, our goal is to take your project from creative to customer as seamlessly as possible. If you still aren’t sure which option will work best for your self-publishing needs, maybe it’s time you contacted a custom printing expert. If your intention is to sell your book, you may find your clients or fans are more likely to purchase one over the other – afterward, you can dedicate your printing efforts to that specific format from now on. If your book doesn’t fall into a specific category that necessitates either hardcover or paperback, you can always print your book in both formats. And sometimes, it’s okay to have it both ways. Whether you’re self-publishing your first novel or simply want a way to remember a special time spent with friends, family, or your community baseball team, the choice between hardcover and paperback is entirely up to you. For instance, if you’re trying to publish a yearbook or commemorative text, it may be best to select hardcover for its durability over paperback’s relative flimsiness.Īlso, if your goal is to be noticed by a traditional publisher, releasing the book in hardcover first may be the best way to catch their attention so they can inquire about the rights to the paperback version – an avenue that doesn’t work the other way around. The paperback category has far more competition in the publishing industry.ĭepending on the nature of your book, hardcover may be the only way to go.Because paperbacks often cost much less than hardcovers, self-publishers may see smaller profits from sales.Paperbacks can become damaged far more easily than their hardcover counterparts.Readers feel better purchasing paperbacks because they are more affordable, allowing them to later purchase hardcovers if they enjoyed the book.Paperbacks are easier to hold and manipulate.Paperbacks are ideal for on-the-go readers due to their portability.Paperbacks allow self-publishing authors more flexibility in spine width and dimensions.By a considerable margin, paperbacks are the most popular style for custom printed books written by self-publishing authors. Each page is attached to the binding with glue. Paperback books, also called softcovers, use heavy glossy or matte cardstock to protect the pages within. Shipping costs are considerably higher for hardcover books at all volumes.Hardcover books are heavier and more difficult to transport or manipulate.Hardcover print costs can be as much as 5x more per copy.Because hardcovers often include a dust jacket, self-publishers can design two unique covers.Hardcovers cost more and can potentially make more money for the selling self-publisher.Hardcovers function as collectible items for both self-publishers and readers. ![]() Hardcovers are more durable and stand the test of time.Hardcovers are the “premium” option for both look and feel.Pages are attached to the binding with glue or are sewn directly onto the binding, which allows for more flexibility when read. While custom book printers for hardcovers vary, most use thick cardboard between 2.5mm and 3.5mm as bindings for their books. Hardcover books, also called hardbacks, are exactly what they sound like: books with hard covers. ![]()
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![]() ![]() In 2009, the FDA determined that moderate renal impairment (eGFR of 30-60) was NOT a risk factor for NSF, reversing the position it had taken in December 2006, and stated 2 “The December information was based upon reports of NSF among patients with purportedly moderate renal insufficiency. ![]() The exact etiology of NSF is unclear but most reported cases have been documented in patients with severe acute or chronic renal failure, with a glomerular filtration rate (GFR) 30 1. NSF is generally seen in the middle-aged, but has also been reported in the elderly and in children. Intravenous requirements for mr contrast agents skin#This rare but serious systemic disease is characterized by fibrosis of the skin and other tissues throughout the body. This changed in 2006 when the FDA first reported the association between nephrogenic systemic fibrosis (NSF) and intravenous gadolinium administration. Intravenous MRI contrast agent safety and Nephrogenic systemic fibrosis are discussed separately.The administration of intravenous gadolinium-containing contrast media was historically considered safe in patients with impaired renal function. Indications for use and efficacy are similar to the other agents. It is a low osmolar, nonionic contrast as is Gadodiamide. Gadoteridol (Prohance, Squibb) is the third intravenous contrast agent on the market. No abnormal serum bilirubin levels occur, however elevated serum iron levels occurred with an incidence of 8.2% in one study of 73 patients.The efficacy of this contrast is similar to that of Gd-DTPA. It has a median lethal dose of 34 mmol/kg resulting in a safety ratio of 2-3 times that of Gd-DOTA, and 3-4 times that of Gd-DTPA. Gadodiamide (Omniscan, Winthrop Pharm.) is a nonionic complex with two-fifths of the osmolality of Gd-DTPA. Ionic chelates are also hyperosmolar and some of their side effects may be attributed to this property. The development of nonionic contrast agents for MRI has paralleled that for iodinated contrast materials. It is distributed in the intravascular and extracellular fluid spaces, does not cross an intact blood-brain-barrier, and is excreted rapidly by glomerular filtration. Gd-DTPA has similar pharmacokinetics as iodinated contrast agents. This large magnetic moment is related to its seven unpaired orbital electrons. Gd has a large magnetic moment, exceeded only by Dysprosium(III) and Holmium(III), explaining its paramagnetic properties at low concentrations. Gd-DTPA was the first intravenous MR contrast agent to be approved for human use (Magnevist, Berlex Labs). Chelates with a higher stability constant have since been used successfully such as Gd-DTPA. IonicsĬhelates of paramagnetic ions Cr and Gd with EDTA were first used however EDTA was of relatively low stability resulting in toxicity in animals . With chelation of these ions, acute toxicity is reduced and elimination rate is increased thereby reducing the chance of long term toxicity. Paramagnetic metal ions suitable as MR contrast agents are all potentially toxic when injected IV at or near doses needed for clinical imaging. NOTE: This article has been transferred from and was last updated in March 5, 1996. The particulates, sequestered in the liver, spleen, and lymph nodes, the intravascular agents, confined to the blood pool, and tumor specific agents are discusses separately (see bottom). ![]() Intravenous MRI contrast agents include chelates of paramagnetic ions, both ionic and nonionic. ![]() ![]() NEWEST UPDATE: Board games! Come play chess, checkers, uno, tictactoe, connectfour, and more! We have constant updates and active staff!Simple and effective spawn! You wont find a massive useless spawn city that contains a few rule signs. □ Cherry Blossom □ was created to give players a feeling of progression and accomplishment while staying simple and close to vanilla, offering a variety of plugins that enhance the minecraft experience such as /sethome, /tpa, /rtp, chest/door locks, and /rest. ¡Únete y encuentra amigos para divertirte!Ĭonnect to this Minecraft 1.17.1 server using the ip mx. Diversión en nuestro servidor de Discord discord.gg/FhJTNRF Atención por parte de los Owners ante dudas del servidor Diferentes rangos VIP con muchas ventajas Lumetown: Zona donde podrás crear tu propia tienda y vender tus ítems Economía en fase Beta, con ítems nuevos todo el tiempo Survival 1.18 ¡Nuevo! (100% vanilla/no hacks) Para dar la bienvenida a la 1.18 hemos actualizado y ahora todas las modalidades son compatibles con la última versión de Minecraft, igualmente se ha añadido un servidor 1.18 survival 100% vanilla para probar todo lo que está versión tiene para nosotros!ĪHORA LUMECRAFT ES COMPATIBLE CON BEDROCK!! ![]() ¡Servidor enfocado en Survival, hagamos de Lumecraft una comunidad bonita y divertida! ¿Preparado para vivir una experiencia nueva?Ĭonnect to this Minecraft 1.17.1 server using the ip ✔ Proyecto respaldado por una empresa registrada legalmente. ✔ Staff activo, maduro y en constante crecimiento. ✔ Concursos donde puedes ganar dinero real. Por lo demás, MineLatino Network es considerado uno de los mejores servidores de Minecraft no premium, pues garantizamos lo siguiente: Pues constantemente actualizamos, con el objetivo de añadir más modalidades y sobre todo, para mantener actualizadas nuestras modalidades actuales. Si te encuentras buscando una experiencia diferente al momento de jugar Minecraft, entonces necesitas entrar a nuestra Network, pues contamos con las siguientes modalidades: ![]() Friendly Community | Although we are a new server, we encourage our future players to beĬonnect to this Minecraft 1.17.1 server using the ip Player-Driven Economy | The Seed sells a limited amount of items at it's shop. Pets | Every player is able to tame their own pet by killing any animal with a lead Rank promotions for playing on the server | Each Rank has it's own upgrades User-Friendly Land Claiming | Protect your property with ease ![]() Player Warps | Once you are a Nomad (play for one hour), you can create public warps Player Shops | Anybody and everybody is allowed to create their own shop While we do have custom features, our goal is to keep The Seed simple and community-based for those that just want to play Minecraft with friends. For the players that are looking for a server that has countless custom-coded features, The Seed isn't for you. The Seed was created with one thing in mind - Minecraft. ![]() ![]()
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